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SSPA,
SUMMER SCHOOL ON PHARMACEUTICAL ANALYSIS
The Summer School on Pharmaceutical Analysis (SSPA) is based on
a three-year program on the most advanced analytical methodologies
involved in the launch of new drugs. The SSPA 2011 edition (I year)
was focused on “Advanced Analytical Methodologies in Drug
Discovery” for characterizing ligand-target interaction through
bioaffinity chromatography with immobilized target proteins, NMR,
MS techniques, luminescence and FRET methods for ligand screening
and hit selection.
The ultimate goal of a drug discovery program is to generate a candidate
drug compound that, besides being active and selective in vitro
on the isolated target, is safe and efficacious in humans. In order
to develop such a compound, many criteria including affinity, activity,
selectivity, physico-chemical properties, and pharmacokinetics must
be optimized. The definition of these criteria involves the availability
and knowledge of appropriate bio-analytical methodologies.
Therefore, following the SSPA 2011, the SSPA 2012 edition (II year)
is oriented on ‘ADVANCED ANALYTICAL METHODOLOGIES IN DRUG
DEVELOPMENT’.
Specifically, the main topics that will be approached during the
school are:
i)
Pharmacokinetic
parameters in drug development.
The following questions will be addressed: how can the in vivo behavior
of a compound under development be determined? What are its clearance,
half life, distribution and metabolic rate? Which methodologies
can be applied to determine these parameters?
ii) In silico prediction
and in vitro determination of ADMET properties.
The following questions will addressed: how can we predict physico-chemical
(PC) and principal ADME (absorption, distribution, metabolism, and
excretion) processes? How can these in silico parameters be integrated
with in vitro pharmacokinetic (PK) data? Which are the most suitable
methodologies to in vitro determine drug metabolism and distribution?
iii) In vivo determination
of ADMET properties:
sample preparation. In in vivo drug metabolism and pharmacokinetic
studies biological samples need to be analyzed. The following question
will be addressed: what are the most efficacious, reliable, accurate
procedures for sample preparation prior to the analysis?
iv) Biomarkers in drug development.
The following questions will be addressed: which methodologies can
be used for rapid and reliable assessment of markers of efficiency
and security of drug under development? Which are the most appropriate
analytical techniques to obtain the fingerprints in a non-target
metabolomic approach? How multivariate data analysis can reveal
a good group clustering and permit the putative assignment of compounds
statistically significant in the classification?
The
tutorial sessions will focus on practical examples and general solutions
to common problems. The use of LC/MS, GC/MS, and NMR will be described,
such as method development for metabolic products by LC-tandem MS
and its application in mammalian cells and in humans. The potential
and limitations of these techniques together with future perspectives
will be also discussed.
The
course is open to a maximum of 80 students and is held in English
language.If you already participated at SSPA previous edition(s),
do not miss this opportunity to enlarge your knowledge on the most
advanced bio-analytical methodologies in drug development by attending
SSPA 2012!
Vincenza
Andrisano
SSPA Director
Under
the auspices of: |
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