Epidermal Sheet Grafts for Vitiligo Repigmentation
Posted on December 22, 2016
Vitiligo gives extreme resistant to any kind of treatment. PUVA is considered as the main therapy but it is expensive, time consuming and only fairly effective. For the treatment of small isolated areas suction blister epidermal grafts, punch grafts, melanocyte grafts and autologous cultured keratinocyte have been experimented but effectiveness vary in all methods.
19 patients having vitiligo and one patient with piebaldism selected to graft thin epidermal sheets obtained from the buttocks with a dermatome air of Zimmer on apparently depigmented, dermabraded skin. To wound the layer for one week with silicone netting, 0.1 mm thick grafting were secured and also covered with saline soaked gauze. Patients were also allowed to move under the sunlight with the grafted skin.
95% to 100% repigmentation was attained by the 64% of the grafted sites after four to 8 months. 50% to 70% repigmentation was achieved by 18% and 18% patients achieve 20% or less repigmentation. And patients having stable vitiligo since last 2 years and piebaldism patients achieved full repigmentation. Patients having progressive vitiligo did not receive repigmentation and grafting in the instant postoperative time also did not get immobilization. Development of milia was also reported in some grafted sites. Donor sites were not depigmented.