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13th
SCPA, ADVANCED ANALYTICAL METHODOLOGIES IN DRUG DISCOVERY
Chairman's
Invitation
On
behalf of the Scientific and Organizing Committees it is my pleasure
to invite you to the 13th Summer Course on Pharmaceutical Analysis
that will take place 21-23 September, 2008 at the Aula Magna, Polo
Scientifico e Didattico di Rimini, Alma Mater Studiorum Università
di Bologna, Via Angherà 22, Rimini, Italy.
Since
2008 the Summer Course on Pharmaceutical Analysis (SCPA) will change
its structure and will cover a three-year
program on the most advanced analytical methodologies
involved into the launch of new drugs, starting from the discovery
phase (hit identification, structure properties relationship), through
drug development (lead optimisation, ADMET studies, biomarkers identification)
ending with formulation quality control and validation. New cycles
will follow in which the most recent analytical topics in the specific
phase will be introduced.
In
2008 the SCPA first year program
is focused on ‘ADVANCED ANALYTICAL
METHODOLOGIES IN DRUG DISCOVERY’. In particular,
the cutting-edge analytical approaches in pharmaceutical profiling
(SPR) and hit identification are examined.
Pharmaceutical profiling is an emerging strategy in drug discovery
and represents an enhancement of the SAR paradigm because properties
have a major effect on in vitro and in vivo pharmacology. Drug discovery
scientists can understand and control more of the variables that
affect their experiments, to achieve increased success. Profiling
data assist the diagnosis of compound performance at various barriers
as well as the prioritisation and optimisation and alerts research
teams to factors that affect development attrition. Properties can
be improved via structural modifications, and best candidate can
be selected for advancement.
High throughput assays lessons and tutorials are scheduled for physicochemical
properties determination for SPR (structure-property relationship).
HTS methods for the determination and optimization of physico-chemical
parameters such as integrity, solubility, permeability,
lipophilicity, pKa, bioavailability, stability, etc. are taught
by eminent scientists in the field. Lessons and tutorials for purpose
methodologies to determine solubility, aggregation and aggregate
dimensions (dynamic light scattering, DLS) and barrier-assay model
are scheduled.
Second day faces analytical tools in supporting the discovery
of new drugs, which require miniaturization to facilitate
the screening of classes of compounds for their binding to the target
protein for hit identification (NMR, optical biosensor), but also
a deeper characterization of the mechanisms involved in the molecular
recognition processes (Circular Dichroism), for probing structure
and folding of target protein and their changes upon binding with
ligands.
Some speakers are going to organize tutorials in the informatic
room to simulate experiments and determine parameters.
The course is open to a maximum of 80 students
and is held in English language. By attending the 13th SCPA, PhD
students will be able to acquire 3 CFU (credits).
Vincenza
Andrisano
Chairman 13th SCPA
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